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Protein function prediction

DeepGOWeb predicts protein functions from sequence using DeepGOPlus and the DeepGO-PlusPlus-Light multi-evidence ensemble. Just paste one or more sequences below. A REST API and a SPARQL endpoint are also available.

Looking for the previous DeepGOWeb release? Use the original KAUST-hosted version.

Prediction model:

Release version (see changelog):

Input Format (FASTA/Raw):

Prediction threshold:

Default: 0.3 for DeepGOPlus, 0.5 for DeepGO-PlusPlus-Light.

Show only the most specific terms (hide redundant ancestors above the threshold)

Sequences:

The number of sequences in one query should not exceed 10.

Try an example

Input

Format: FASTA, or raw sequences separated by a newline.
Threshold: 0.1–1.0, filters predictions by confidence.
Data: protein sequences in the selected format.

Output

GO terms for Biological Process, Molecular Function and Cellular Component with confidence scores, plus similar proteins. See the documentation. Results are CC-BY and downloadable as JSON/CSV/RDF.

>sp|P80386|AAKB1_RAT 5'-AMP-activated protein kinase subunit beta-1 OS=Rattus norvegicus GN=Prkab1 PE=1 SV=4 MGNTSSERAALERQAGHKTPRRDSSGGTKDGDRPKILMDSPEDADIFHTEEMKAPEKEEF LAWQHDLEVNEKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPE GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS SSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY ALSIKDGVMVLSATHRYKKKYVTTLLYKPI

MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL